PKM2 promotes glucose metabolism and cell growth in gliomas through a mechanism involving a let-7a/c-Myc/hnRNPA1 feedback loop

Tumor cells metabolize more glucose to lactate in aerobic or hypoxic conditions than non-tumor cells. Pyruvate kinase isoenzyme type M2 (PKM2) is crucial for tumor cell aerobic glycolysis. We established a role for let-7a/c-Myc/hnRNPA1/PKM2 signaling in glioma cell glucose metabolism. PKM2 depletion...

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Detalhes bibliográficos
Publicado no:Oncotarget
Principais autores: Luan, Wenkang, Wang, Yingyi, Chen, Xincheng, Shi, Yan, Wang, Jiajia, Zhang, Junxia, Qian, Jin, Li, Ri, Tao, Tao, Wei, Wenjin, Hu, Qi, Liu, Ning, You, Yongping
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536995/
https://ncbi.nlm.nih.gov/pubmed/25948776
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