STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity

BACKGROUND: Alzheimer disease (AD) is a disease of lost memories. Mushroom postsynaptic spines play a key role in memory storage, and loss of mushroom spines has been proposed to be linked to memory loss in AD. Generation of amyloidogenic peptides and accumulation of amyloid plaques is one of the pa...

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Publicado en:Mol Neurodegener
Autores principales: Popugaeva, Elena, Pchitskaya, Ekaterina, Speshilova, Anastasiya, Alexandrov, Sergey, Zhang, Hua, Vlasova, Olga, Bezprozvanny, Ilya
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536802/
https://ncbi.nlm.nih.gov/pubmed/26275606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0034-7
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