STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity

BACKGROUND: Alzheimer disease (AD) is a disease of lost memories. Mushroom postsynaptic spines play a key role in memory storage, and loss of mushroom spines has been proposed to be linked to memory loss in AD. Generation of amyloidogenic peptides and accumulation of amyloid plaques is one of the pa...

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Bibliografiske detaljer
Udgivet i:Mol Neurodegener
Main Authors: Popugaeva, Elena, Pchitskaya, Ekaterina, Speshilova, Anastasiya, Alexandrov, Sergey, Zhang, Hua, Vlasova, Olga, Bezprozvanny, Ilya
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536802/
https://ncbi.nlm.nih.gov/pubmed/26275606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0034-7
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