Early severe impairment of hematopoietic stem and progenitor cells from the bone marrow caused by CLP sepsis and endotoxemia in a humanized mice model

INTRODUCTION: An effective immune response to severe bacterial infections requires a robust production of the innate immunity cells from hematopoietic stem and progenitor cells (HSPCs) in a process called emergency myelopoiesis. In sepsis, an altered immune response that leads to a failure of bacter...

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Bibliographic Details
Published in:Stem Cell Res Ther
Main Authors: Skirecki, Tomasz, Kawiak, Jerzy, Machaj, Eugeniusz, Pojda, Zygmunt, Wasilewska, Danuta, Czubak, Jarosław, Hoser, Grażyna
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536694/
https://ncbi.nlm.nih.gov/pubmed/26272069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-015-0135-9
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