Factor VIII gene variants and inhibitor risk in African American hemophilia A patients

African American hemophilia A (HA) patients experience a higher incidence of neutralizing anti-factor VIII (FVIII) antibodies (“inhibitors”) vis-à-vis white patients. Nonsynonymous single-nucleotide polymorphisms (ns-SNPs) in the F8 gene encoding FVIII-H484, FVIII-E1241, and FVIII-V2238 are more pre...

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Publicado en:Blood
Autores principales: Gunasekera, Devi, Ettinger, Ruth A., Nakaya Fletcher, Shelley, James, Eddie A., Liu, Maochang, Barrett, John C., Withycombe, Janice, Matthews, Dana C., Epstein, Melinda S., Hughes, Richard J., Pratt, Kathleen P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2015
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536543/
https://ncbi.nlm.nih.gov/pubmed/25617427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-599365
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