Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and Disease

PAX6 is a master regulatory gene involved in neuronal cell fate specification. It also plays a critical role in early eye field and subsequent limbal stem cell (LSC) determination during eye development. Defects in Pax6 cause aniridia and LSC deficiency in humans and the Sey (Small eye) phenotype in...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Li, Gen, Xu, Fan, Zhu, Jie, Krawczyk, Michal, Zhang, Ying, Yuan, Jin, Patel, Sherrinal, Wang, Yujuan, Lin, Ying, Zhang, Ming, Cai, Huimin, Chen, Daniel, Zhang, Meixia, Cao, Guiqun, Yeh, Emily, Lin, Danni, Su, Qiao, Li, Wen-wen, Sen, George L., Afshari, Natalie, Chen, Shaochen, Maas, Richard L., Fu, Xiang-Dong, Zhang, Kang, Liu, Yizhi, Ouyang, Hong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2015
Aiheet:
Cell Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536450/
https://ncbi.nlm.nih.gov/pubmed/26045558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662940
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