Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis

Breakdown of the major sleep-promoting neurotransmitter, γ-aminobutyric acid (GABA), in the GABA shunt generates catabolites that may enter the tricarboxylic acid cycle, but it is unknown whether catabolic by-products of the GABA shunt actually support metabolic homeostasis. In Drosophila, the loss...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Maguire, Sarah E., Rhoades, Seth, Chen, Wen-Feng, Sengupta, Arjun, Yue, Zhifeng, Lim, Jason C., Mitchell, Claire H., Weljie, Aalim M., Sehgal, Amita
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536446/
https://ncbi.nlm.nih.gov/pubmed/26124278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.602276
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