Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution.

The rearrangement of immunoglobulin genes in B-lymphocyte precursors requires the expression of the recombination activating genes (Rag), which leads to the generation of a highly diverse B-cell repertoire. We can use the level of Rag-1 mRNA in the bone marrow as an index of its capacity to support...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Ben-Yehuda, A, Szabo, P, Dyall, R, Weksler, M E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45361/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7991570/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.11988
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