Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution.

The rearrangement of immunoglobulin genes in B-lymphocyte precursors requires the expression of the recombination activating genes (Rag), which leads to the generation of a highly diverse B-cell repertoire. We can use the level of Rag-1 mRNA in the bone marrow as an index of its capacity to support...

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Detaylı Bibliyografya
Asıl Yazarlar: Ben-Yehuda, A, Szabo, P, Dyall, R, Weksler, M E
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1994
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC45361/
https://ncbi.nlm.nih.gov/pubmed/7991570
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