Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution.
The rearrangement of immunoglobulin genes in B-lymphocyte precursors requires the expression of the recombination activating genes (Rag), which leads to the generation of a highly diverse B-cell repertoire. We can use the level of Rag-1 mRNA in the bone marrow as an index of its capacity to support...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1994
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45361/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7991570/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.11988 |
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