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Exploiting Translational Stalling Peptides in an Effort to Extend Azithromycin Interaction Within the Prokaryotic Ribosome Nascent Peptide Exit Tunnel
The ribosome is the primary protein synthesis machine in the cell and is a target for treatment of a variety of diseases including bacterial infection and cancer. The ribosomal peptide exit tunnel, the route of egress for the nascent peptide, is an inviting site for drug design. Toward a rational en...
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| Publicado en: | Bioorg Med Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4536091/ https://ncbi.nlm.nih.gov/pubmed/26037612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.04.078 |
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