Insulin Protects Cardiac Myocytes from Doxorubicin Toxicity by Sp1-Mediated Transactivation of Survivin

Insulin inhibits ischemia/reperfusion-induced myocardial apoptosis through the PI3K/Akt/mTOR pathway. Survivin is a key regulator of anti-apoptosis against doxorubicin-induced cardiotoxicity. Insulin increases survivin expression in cardiac myocytes to mediate cytoprotection. However, the mechanism...

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Udgivet i:PLoS One
Main Authors: Lee, Beom Seob, Oh, Jaewon, Kang, Sung Ku, Park, Sungha, Lee, Sang-Hak, Choi, Donghoon, Chung, Ji Hyung, Chung, Youn Wook, Kang, Seok-Min
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535909/
https://ncbi.nlm.nih.gov/pubmed/26271039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135438
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