Insulin Protects Cardiac Myocytes from Doxorubicin Toxicity by Sp1-Mediated Transactivation of Survivin

Insulin inhibits ischemia/reperfusion-induced myocardial apoptosis through the PI3K/Akt/mTOR pathway. Survivin is a key regulator of anti-apoptosis against doxorubicin-induced cardiotoxicity. Insulin increases survivin expression in cardiac myocytes to mediate cytoprotection. However, the mechanism...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:PLoS One
मुख्य लेखकों: Lee, Beom Seob, Oh, Jaewon, Kang, Sung Ku, Park, Sungha, Lee, Sang-Hak, Choi, Donghoon, Chung, Ji Hyung, Chung, Youn Wook, Kang, Seok-Min
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2015
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535909/
https://ncbi.nlm.nih.gov/pubmed/26271039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135438
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