KIF5B-RET Fusion gene may coincide oncogenic mutations of EGFR or KRAS gene in lung adenocarcinomas

BACKGROUND: The KIF5B-RET rearrangement is detected with the frequency of 1 ~ 2 % in ‘triple marker’-negative lung adenocarcinomas, i.e., EGFR, KRAS and EML4-ALK wild type. These mutational changes are known to be mutually exclusive, but the co-existence of ALK rearrangement with activating mutation...

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Dettagli Bibliografici
Pubblicato in:Diagn Pathol
Autori principali: Kim, Jeong-Oh, Lee, Jieun, Shin, Jung-Young, Oh, Ji-Eun, Jung, Chan-Kwon, Park, Jae Kil, Sung, Sook-Whan, Bae, Sang-Ju, Min, Hyun-Jung, Kim, Dowon, Park, Jae Yong, Kang, Jin-Hyoung
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535765/
https://ncbi.nlm.nih.gov/pubmed/26268359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13000-015-0368-z
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