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Prodrug approach to improve absorption of prednisolone
Amino acid and dipeptide prodrugs have been developed to examine their potential in enhancing aqueous solubility and permeability as well as to bypass P-glycoprotein (P-gp) mediated cellular efflux of prednisolone. Prodrugs have been synthesized and identified with LC/MS/MS and NMR. Prodrugs display...
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| Publicado no: | Int J Pharm |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4535455/ https://ncbi.nlm.nih.gov/pubmed/25888804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2015.04.029 |
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