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PARP inhibitors in the management of breast cancer: current data and future prospects
Poly(ADP-ribose) polymerases (PARP) are enzymes involved in DNA-damage repair. Inhibition of PARPs is a promising strategy for targeting cancers with defective DNA-damage repair, including BRCA1 and BRCA2 mutation-associated breast and ovarian cancers. Several PARP inhibitors are currently in trials...
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| Publicado no: | BMC Med |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4535298/ https://ncbi.nlm.nih.gov/pubmed/26268938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-015-0425-1 |
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