Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development

Jarid2 is part of the Polycomb Repressor complex 2 (PRC2) responsible for genome-wide H3K27me3 deposition. Unlike other PRC2-deficient embryonic stem cells (ESCs), however, Jarid2-deficient ESCs show a severe differentiation block, altered colony morphology, and distinctive patterns of deregulated g...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Landeira, David, Bagci, Hakan, Malinowski, Andrzej R., Brown, Karen E., Soza-Ried, Jorge, Feytout, Amelie, Webster, Zoe, Ndjetehe, Elodie, Cantone, Irene, Asenjo, Helena G., Brockdorff, Neil, Carroll, Thomas, Merkenschlager, Matthias, Fisher, Amanda G.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534826/
https://ncbi.nlm.nih.gov/pubmed/26190104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.060
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