Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity

The ototoxic aminoglycoside antibiotics are essential to treat severe bacterial infections, particularly in neonatal intensive care units. Using a bacterial lipopolysaccharide (LPS) experimental model of sepsis, we tested whether LPS-mediated inflammation potentiates cochlear uptake of aminoglycosid...

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Publicado en:Sci Transl Med
Main Authors: Koo, J.-W., Quintanilla-Dieck, L., Jiang, M., Liu, J., Urdang, Z. D., Allensworth, J. J., Cross, C. P., Li, H., Steyger, P. S.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534720/
https://ncbi.nlm.nih.gov/pubmed/26223301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac5546
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