Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee()

Human monoclonal antibody CH58 isolated from an RV144 vaccinee binds at Lys169 of the HIV-1 Env gp120 V2 region, a site of vaccine-induced immune pressure. CH58 neutralizes HIV-1 CRF_01 AE strain 92TH023 and mediates ADCC against CD4 + T cell targets infected with CRF_01 AE tier 2 virus. CH58 and ot...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Nicely, Nathan I., Wiehe, Kevin, Kepler, Thomas B., Jaeger, Frederick H., Dennison, S. Moses, Rerks-Ngarm, Supachai, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Robb, Merlin L., O'Connell, Robert J., Michael, Nelson L., Kim, Jerome H., Liao, Hua-Xin, Munir Alam, S., Hwang, Kwan-Ki, Bonsignori, Mattia, Haynes, Barton F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534707/
https://ncbi.nlm.nih.gov/pubmed/26288844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.06.016
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