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Lack of the Transcription Factor Hypoxia-Inducible Factor 1α (HIF-1α) in Macrophages Accelerates the Necrosis of Mycobacterium avium-Induced Granulomas

The establishment of mycobacterial infection is characterized by the formation of granulomas, which are well-organized aggregates of immune cells, namely, infected macrophages. The granuloma's main function is to constrain and prevent dissemination of the mycobacteria while focusing the immune...

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Bibliografski detalji
Izdano u:Infect Immun
Glavni autori: Cardoso, Marcos S., Silva, Tânia M., Resende, Mariana, Appelberg, Rui, Borges, Margarida
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534669/
https://ncbi.nlm.nih.gov/pubmed/26099585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00144-15
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