Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity

Recently, we showed that endothelial heparan sulfate facilitates entry of a bacterial pathogen into the central nervous system. Here, we show that normal bactericidal activity of neutrophils is influenced by the sulfation pattern of heparan sulfate. Inactivation of heparan sulfate uronyl 2-O-sulfotr...

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Udgivet i:Infect Immun
Main Authors: Xu, Ding, Olson, Joshua, Cole, Jason N., van Wijk, Xander M., Brinkmann, Volker, Zychlinsky, Arturo, Nizet, Victor, Esko, Jeffrey D., Chang, Yung-Chi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Host Response and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534644/
https://ncbi.nlm.nih.gov/pubmed/26150541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00545-15
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