Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

PURPOSE: Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent medulloblastoma (MB). PATIENTS AND METHODS: Adult patients enrolled onto PBTC-025B and pediatric patients enrolled onto PBTC-032 w...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Clin Oncol
Main Authors: Robinson, Giles W., Orr, Brent A., Wu, Gang, Gururangan, Sridharan, Lin, Tong, Qaddoumi, Ibrahim, Packer, Roger J., Goldman, Stewart, Prados, Michael D., Desjardins, Annick, Chintagumpala, Murali, Takebe, Naoko, Kaste, Sue C., Rusch, Michael, Allen, Sariah J., Onar-Thomas, Arzu, Stewart, Clinton F., Fouladi, Maryam, Boyett, James M., Gilbertson, Richard J., Curran, Tom, Ellison, David W., Gajjar, Amar
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society of Clinical Oncology 2015
נושאים:
ORIGINAL REPORTS
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534527/
https://ncbi.nlm.nih.gov/pubmed/26169613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.60.1591
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