Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

PURPOSE: Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent medulloblastoma (MB). PATIENTS AND METHODS: Adult patients enrolled onto PBTC-025B and pediatric patients enrolled onto PBTC-032 w...

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Bibliographic Details
Published in:J Clin Oncol
Main Authors: Robinson, Giles W., Orr, Brent A., Wu, Gang, Gururangan, Sridharan, Lin, Tong, Qaddoumi, Ibrahim, Packer, Roger J., Goldman, Stewart, Prados, Michael D., Desjardins, Annick, Chintagumpala, Murali, Takebe, Naoko, Kaste, Sue C., Rusch, Michael, Allen, Sariah J., Onar-Thomas, Arzu, Stewart, Clinton F., Fouladi, Maryam, Boyett, James M., Gilbertson, Richard J., Curran, Tom, Ellison, David W., Gajjar, Amar
Format: Artigo
Language:Inglês
Published: American Society of Clinical Oncology 2015
Subjects:
ORIGINAL REPORTS
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534527/
https://ncbi.nlm.nih.gov/pubmed/26169613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.60.1591
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