Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

PURPOSE: Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent medulloblastoma (MB). PATIENTS AND METHODS: Adult patients enrolled onto PBTC-025B and pediatric patients enrolled onto PBTC-032 w...

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書誌詳細
出版年:J Clin Oncol
主要な著者: Robinson, Giles W., Orr, Brent A., Wu, Gang, Gururangan, Sridharan, Lin, Tong, Qaddoumi, Ibrahim, Packer, Roger J., Goldman, Stewart, Prados, Michael D., Desjardins, Annick, Chintagumpala, Murali, Takebe, Naoko, Kaste, Sue C., Rusch, Michael, Allen, Sariah J., Onar-Thomas, Arzu, Stewart, Clinton F., Fouladi, Maryam, Boyett, James M., Gilbertson, Richard J., Curran, Tom, Ellison, David W., Gajjar, Amar
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Clinical Oncology 2015
主題:
ORIGINAL REPORTS
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534527/
https://ncbi.nlm.nih.gov/pubmed/26169613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.60.1591
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