Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Wang, Yuxuan, Springer, Simeon, Zhang, Ming, McMahon, K. Wyatt, Kinde, Isaac, Dobbyn, Lisa, Ptak, Janine, Brem, Henry, Chaichana, Kaisorn, Gallia, Gary L., Gokaslan, Ziya L., Groves, Mari L., Jallo, George I., Lim, Michael, Olivi, Alessandro, Quinones-Hinojosa, Alfredo, Rigamonti, Daniele, Riggins, Greg J., Sciubba, Daniel M., Weingart, Jon D., Wolinsky, Jean-Paul, Ye, Xiaobu, Oba-Shinjo, Sueli Mieko, Marie, Suely K. N., Holdhoff, Matthias, Agrawal, Nishant, Diaz, Luis A., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Bettegowda, Chetan
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534284/
https://ncbi.nlm.nih.gov/pubmed/26195750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511694112
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