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Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA...

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הוצא לאור ב:	Proc Natl Acad Sci U S A
Main Authors:	Wang, Yuxuan, Springer, Simeon, Zhang, Ming, McMahon, K. Wyatt, Kinde, Isaac, Dobbyn, Lisa, Ptak, Janine, Brem, Henry, Chaichana, Kaisorn, Gallia, Gary L., Gokaslan, Ziya L., Groves, Mari L., Jallo, George I., Lim, Michael, Olivi, Alessandro, Quinones-Hinojosa, Alfredo, Rigamonti, Daniele, Riggins, Greg J., Sciubba, Daniel M., Weingart, Jon D., Wolinsky, Jean-Paul, Ye, Xiaobu, Oba-Shinjo, Sueli Mieko, Marie, Suely K. N., Holdhoff, Matthias, Agrawal, Nishant, Diaz, Luis A., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Bettegowda, Chetan
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	National Academy of Sciences 2015
נושאים:	Biological Sciences
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4534284/ https://ncbi.nlm.nih.gov/pubmed/26195750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511694112
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Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

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