Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Wang, Yuxuan, Springer, Simeon, Zhang, Ming, McMahon, K. Wyatt, Kinde, Isaac, Dobbyn, Lisa, Ptak, Janine, Brem, Henry, Chaichana, Kaisorn, Gallia, Gary L., Gokaslan, Ziya L., Groves, Mari L., Jallo, George I., Lim, Michael, Olivi, Alessandro, Quinones-Hinojosa, Alfredo, Rigamonti, Daniele, Riggins, Greg J., Sciubba, Daniel M., Weingart, Jon D., Wolinsky, Jean-Paul, Ye, Xiaobu, Oba-Shinjo, Sueli Mieko, Marie, Suely K. N., Holdhoff, Matthias, Agrawal, Nishant, Diaz, Luis A., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Bettegowda, Chetan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534284/
https://ncbi.nlm.nih.gov/pubmed/26195750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511694112
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