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Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin
Point mutations in vascular smooth muscle α-actin (SM α-actin), encoded by the gene ACTA2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD). Here, we provide the first molecular characterization, to our knowledge, of the effect of the R258C mutation in SM α-a...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4534267/ https://ncbi.nlm.nih.gov/pubmed/26153420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507587112 |
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