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In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity

The importance and effect of Fc glycosylation of monoclonal antibodies with regard to biological activity is widely discussed and has been investigated in numerous studies. Fc glycosylation of monoclonal antibodies from current production systems is subject to batch-to-batch variability. If there ar...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Thomann, Marco, Schlothauer, Tilman, Dashivets, Tetyana, Malik, Sebastian, Avenal, Cecile, Bulau, Patrick, Rüger, Petra, Reusch, Dietmar
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534130/
https://ncbi.nlm.nih.gov/pubmed/26266936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134949
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