Enzymatic Mechanism of Leishmania major Peroxidase and the Critical Role of Specific Ionic Interactions

Leishmania major peroxidase (LmP) is very similar to the well-known yeast cytochrome c peroxidase (CcP). Both enzymes catalyze the peroxidation of cytochrome c. Like CcP, LmP reacts with H(2)O(2) to form Compound I, which consists of a ferryl heme and a Trp radical, Fe(IV)= O;Trp(•+). Cytochrome c (...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Chreifi, Georges, Hollingsworth, Scott A., Li, Huiying, Tripathi, Sarvind, Arce, Anton P., Magaña-Garcia, Hugo I., Poulos, Thomas L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533909/
https://ncbi.nlm.nih.gov/pubmed/25941976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00338
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