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Triazolophostins: a library of novel and potent agonists of IP(3) receptors

IP(3) receptors are channels that mediate the release of Ca(2+) from the intracellular stores of cells stimulated by hormones or neurotransmitters. Adenophostin A (AdA) is the most potent agonist of IP(3) receptors, with the β-anomeric adenine contributing to the increased potency. The potency of Ad...

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Pubblicato in:Org Biomol Chem
Autori principali: Vibhute, Amol M., Konieczny, Vera, Taylor, Colin W., Sureshan, Kana M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533600/
https://ncbi.nlm.nih.gov/pubmed/25869535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob00440c
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