Structure-based Design of Peptides with High Affinity and Specificity to HER2 Positive Tumors

To identify peptides with high affinity and specificity against human epidermal growth factor receptor 2 (HER2), a series of peptides were designed based on the structure of HER2 and its Z(HER2:342) affibody. By using a combination protocol of molecular dynamics modeling, MM/GBSA binding free energy...

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Bibliographische Detailangaben
Veröffentlicht in:Theranostics
Hauptverfasser: Geng, Lingling, Wang, Zihua, Yang, Xiaoliang, Li, Dan, Lian, Wenxi, Xiang, Zhichu, Wang, Weizhi, Bu, Xiangli, Lai, Wenjia, Hu, Zhiyuan, Fang, Qiaojun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533098/
https://ncbi.nlm.nih.gov/pubmed/26284145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.12398
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