S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer's Disease

Among the different signaling molecules released during reactive gliosis occurring in Alzheimer's disease (AD), the astrocyte-derived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease. The use of pharmacological tools targeting S100B may be crucial to emba...

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Publicat a:Biomed Res Int
Autors principals: Cirillo, Carla, Capoccia, Elena, Iuvone, Teresa, Cuomo, Rosario, Sarnelli, Giovanni, Steardo, Luca, Esposito, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532807/
https://ncbi.nlm.nih.gov/pubmed/26295040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/508342
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