S100B-p53 disengagement by pentamidine promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells

S100 calcium-binding protein B (S100B) is highly expressed in glioma cells and promotes cancer cell survival via inhibition of the p53 protein. In melanoma cells, this S100B-p53 interaction is known to be inhibited by pentamidine isethionate, an antiprotozoal agent. Thus, the aim of the present stud...

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Vydáno v:Oncol Lett
Hlavní autoři: CAPOCCIA, ELENA, CIRILLO, CARLA, MARCHETTO, ANNALISA, TIBERI, SAMANTA, SAWIKR, YOUSSEF, PESCE, MARCELLA, D'ALESSANDRO, ALESSANDRA, SCUDERI, CATERINA, SARNELLI, GIOVANNI, CUOMO, ROSARIO, STEARDO, LUCA, ESPOSITO, GIUSEPPE
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473713/
https://ncbi.nlm.nih.gov/pubmed/26137161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2015.3091
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