Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing

Prelamin A accumulation and persistent DNA damage response (DDR) are hallmarks of vascular smooth muscle cell (VSMC) ageing and dysfunction. Although prelamin A is proposed to interfere with DNA repair, our understanding of the crosstalk between prelamin A and the repair process remains limited. The...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Warren, D T, Tajsic, T, Porter, L J, Minaisah, R M, Cobb, A, Jacob, A, Rajgor, D, Zhang, Q P, Shanahan, C M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532777/
https://ncbi.nlm.nih.gov/pubmed/25744025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.12
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