Novel Nuclear Nesprin-2 Variants Tether Active Extracellular Signal-regulated MAPK1 and MAPK2 at Promyelocytic Leukemia Protein Nuclear Bodies and Act to Regulate Smooth Muscle Cell Proliferation

Nuclear and cytoplasmic scaffold proteins have been shown to be essential for temporal and spatial organization, as well as the fidelity, of MAPK signaling pathways. In this study we show that nesprin-2 is a novel extracellular signal-regulated MAPK1 and 2 (ERK1/2) scaffold protein that serves to re...

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Detalhes bibliográficos
Main Authors: Warren, Derek T., Tajsic, Tamara, Mellad, Jason A., Searles, Richelle, Zhang, Qiuping, Shanahan, Catherine M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801258/
https://ncbi.nlm.nih.gov/pubmed/19861416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032557
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