Validation of Next-Generation Sequencing of Entire Mitochondrial Genomes and the Diversity of Mitochondrial DNA Mutations in Oral Squamous Cell Carcinoma

BACKGROUND: Oral squamous cell carcinoma (OSCC) is mainly caused by smoking and alcohol abuse and shows a five-year survival rate of ~50%. We aimed to explore the variation of somatic mitochondrial DNA (mtDNA) mutations in primary oral tumors, recurrences and metastases. METHODS: We performed an in-...

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Publicado no:PLoS One
Main Authors: Kloss-Brandstätter, Anita, Weissensteiner, Hansi, Erhart, Gertraud, Schäfer, Georg, Forer, Lukas, Schönherr, Sebastian, Pacher, Dominic, Seifarth, Christof, Stöckl, Andrea, Fendt, Liane, Sottsas, Irma, Klocker, Helmut, Huck, Christian W., Rasse, Michael, Kronenberg, Florian, Kloss, Frank R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532422/
https://ncbi.nlm.nih.gov/pubmed/26262956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135643
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