Analyzing Low-Level mtDNA Heteroplasmy—Pitfalls and Challenges from Bench to Benchmarking

Massive parallel sequencing technologies are promising a highly sensitive detection of low-level mutations, especially in mitochondrial DNA (mtDNA) studies. However, processes from DNA extraction and library construction to bioinformatic analysis include several varying tasks. Further, there is no v...

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Bibliografiske detaljer
Udgivet i:	Int J Mol Sci
Main Authors:	Fazzini, Federica, Fendt, Liane, Schönherr, Sebastian, Forer, Lukas, Schöpf, Bernd, Streiter, Gertraud, Losso, Jamie Lee, Kloss-Brandstätter, Anita, Kronenberg, Florian, Weissensteiner, Hansi
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI 2021
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7832847/ https://ncbi.nlm.nih.gov/pubmed/33477827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22020935
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Analyzing Low-Level mtDNA Heteroplasmy—Pitfalls and Challenges from Bench to Benchmarking

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