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Analyzing Low-Level mtDNA Heteroplasmy—Pitfalls and Challenges from Bench to Benchmarking

Massive parallel sequencing technologies are promising a highly sensitive detection of low-level mutations, especially in mitochondrial DNA (mtDNA) studies. However, processes from DNA extraction and library construction to bioinformatic analysis include several varying tasks. Further, there is no v...

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Bibliografski detalji
Izdano u:Int J Mol Sci
Glavni autori: Fazzini, Federica, Fendt, Liane, Schönherr, Sebastian, Forer, Lukas, Schöpf, Bernd, Streiter, Gertraud, Losso, Jamie Lee, Kloss-Brandstätter, Anita, Kronenberg, Florian, Weissensteiner, Hansi
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7832847/
https://ncbi.nlm.nih.gov/pubmed/33477827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22020935
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