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Sequential design of phase II–III cancer trials
Although traditional phase II cancer trials are usually single arm, with tumor response as endpoint, and phase III trials are randomized and incorporate interim analyses with progression-free survival or other failure time as endpoint, this paper proposes a new approach that seamlessly expands a ran...
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| Publicado en: | Stat Med |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4532356/ https://ncbi.nlm.nih.gov/pubmed/22422502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5346 |
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