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Sequential design of phase II–III cancer trials

Although traditional phase II cancer trials are usually single arm, with tumor response as endpoint, and phase III trials are randomized and incorporate interim analyses with progression-free survival or other failure time as endpoint, this paper proposes a new approach that seamlessly expands a ran...

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Detalhes bibliográficos
Publicado no:Stat Med
Main Authors: Lai, Tze Leung, Lavori, Philip W., Shih, Mei-Chiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532356/
https://ncbi.nlm.nih.gov/pubmed/22422502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5346
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