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A New Approach to Designing Phase I-II Cancer Trials for Cytotoxic Chemotherapies
Recently there has been much work on early phase cancer designs that incorporate both toxicity and efficacy data, called Phase I-II designs because they combine elements of both phases. However, they do not explicitly address the Phase II hypothesis test of H(0): p ≤ p(0), where p is the probability...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4048734/ https://ncbi.nlm.nih.gov/pubmed/24577750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6124 |
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