Protective Effect of Chlormethiazole, a Sedative, against Acetaminophen-Induced Liver Injury in Mice

OBJECTIVES: The hepatotoxicity of acetaminophen is not a result of the parent compound but is mediated by its reactive metabolite N-acetyl-p-benzoquinone imine. Cytochrome P4502E1 (CYP2E1) is the principal enzyme of this biotransformation, which accounts for approximately 52% of the bioactivation in...

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Veröffentlicht in:Korean J Intern Med
Hauptverfasser: Lee, Han Chu, Jung, Sung Ae, Jung, Hye Kyung, Yi, Sun Young, Kim, Doe Young, Moon, Il Hwan, Park, Sung Su
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korean Association of Internal Medicine 1999
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4531924/
https://ncbi.nlm.nih.gov/pubmed/10461422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3904/kjim.1999.14.2.27
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