Isoguanine and 5-Methyl-Isocytosine Bases, In Vitro and In Vivo

The synthesis, base-pairing properties and in vitro and in vivo characteristics of 5-methyl-isocytosine (isoC(Me)) and isoguanine (isoG) nucleosides, incorporated in an HNA(h) (hexitol nucleic acid)–DNA(d) mosaic backbone, are described. The required h-isoG phosphoramidite was prepared by a selectiv...

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Publicado en:Chemistry
Main Authors: Bande, Omprakash, Abu El Asrar, Rania, Braddick, Darren, Dumbre, Shrinivas, Pezo, Valérie, Schepers, Guy, Pinheiro, Vitor B, Lescrinier, Eveline, Holliger, Philipp, Marlière, Philippe, Herdewijn, Piet
Formato: Artigo
Idioma:Inglês
Publicado: WILEY-VCH Verlag 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4531829/
https://ncbi.nlm.nih.gov/pubmed/25684598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201406392
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