Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins

Xenobiotic nucleic acids (XNA) are nucleic acid analogues not present in nature that can be used for the storage of genetic information. In vivo XNA applications could be developed into novel biocontainment strategies, but are currently limited by the challenge of developing XNA processing enzymes s...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Vanmeert, Michiel, Razzokov, Jamoliddin, Mirza, Muhammad Usman, Weeks, Stephen D, Schepers, Guy, Bogaerts, Annemie, Rozenski, Jef, Froeyen, Mathy, Herdewijn, Piet, Pinheiro, Vitor B, Lescrinier, Eveline
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Synthetic Biology and Bioengineering
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6649754/
https://ncbi.nlm.nih.gov/pubmed/31334814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz551
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