Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

We have generated transgenic mouse lines carrying and expressing wild-type and 3'-modified human tumour necrosis factor (hTNF-alpha, cachectin) transgenes. We show that correct, endotoxin-responsive and macrophage-specific hTNF gene expression can be established in transgenic mice and we present evi...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Keffer, J, Probert, L, Cazlaris, H, Georgopoulos, S, Kaslaris, E, Kioussis, D, Kollias, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC453150/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1721867/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb04978.x
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