Ligand-induced proton transfer and low-barrier hydrogen bond revealed by X-ray crystallography

Ligand binding can change the pKa of protein residues and influence enzyme catalysis. Herein, we report three ultrahigh resolution X-ray crystal structures of CTX-M β-lactamase, directly visualizing protonation state changes along the enzymatic pathway: apo protein at 0.79 Å, pre-covalent complex wi...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Nichols, Derek A., Hargis, Jacqueline C., Sanishvili, Ruslan, Jaishankar, Priyadarshini, Defrees, Kyle, Smith, Emmanuel, Wang, Kenneth K., Prati, Fabio, Renslo, Adam R., Woodcock, H. Lee, Chen, Yu
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530788/
https://ncbi.nlm.nih.gov/pubmed/26057252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b00749
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