Three–dimensional (3D) culture of bone–derived human 786–O renal cell carcinoma retains relevant clinical characteristics of bone metastases

Bone metastases from renal cell carcinoma (RCC) are typically lytic, destructive, and resistant to treatment regimens. Current in vitro models for studying metastasis introduce artifacts that limit their usefulness. Many features of tumors growing in bone are lost when human RCC cells are cultured i...

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Veröffentlicht in:Cancer Lett
Hauptverfasser: Pan, Tianhong, Fong, Eliza L.S., Martinez, Mariane, Harrington, Daniel A., Lin, Sue-Hwa, Farach-Carson, Mary C., Satcher, Robert L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530612/
https://ncbi.nlm.nih.gov/pubmed/26004343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.05.019
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