Hepatic Dimethylarginine-Dimethylaminohydrolase1 is Reduced in Cirrhosis and is a Target for Therapy in Portal Hypertension

BACKGROUND AND AIMS: Portal hypertension is characterized by reduced hepatic eNOS activity. Asymmetric-dimethylarginine (ADMA), an eNOS inhibitor, is elevated in cirrhosis and correlates with severity of portal hypertension. Dimethylargininedimethylaminohydrolase-1 (DDAH-1) is the key enzyme metabol...

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Publicat a:J Hepatol
Autors principals: Mookerjee, Rajeshwar P, Mehta, Gautam, Balasubramaniyan, Vairappan, Mohamed, Fatma, Davies, Nathan, Sharma, Vikram, Iwakiri, Yasuko, Jalan, Rajiv
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530584/
https://ncbi.nlm.nih.gov/pubmed/25152204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.08.024
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