Hepatic Dimethylarginine-Dimethylaminohydrolase1 is Reduced in Cirrhosis and is a Target for Therapy in Portal Hypertension

BACKGROUND AND AIMS: Portal hypertension is characterized by reduced hepatic eNOS activity. Asymmetric-dimethylarginine (ADMA), an eNOS inhibitor, is elevated in cirrhosis and correlates with severity of portal hypertension. Dimethylargininedimethylaminohydrolase-1 (DDAH-1) is the key enzyme metabol...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Hepatol
Hlavní autoři: Mookerjee, Rajeshwar P, Mehta, Gautam, Balasubramaniyan, Vairappan, Mohamed, Fatma, Davies, Nathan, Sharma, Vikram, Iwakiri, Yasuko, Jalan, Rajiv
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530584/
https://ncbi.nlm.nih.gov/pubmed/25152204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.08.024
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky