Cargando...
Slow mitochondrial repair of 5′-AMP renders mtDNA susceptible to damage in APTX deficient cells
Aborted DNA ligation events in eukaryotic cells can generate 5′-adenylated (5′-AMP) DNA termini that can be removed from DNA by aprataxin (APTX). Mutations in APTX cause an inherited human disease syndrome characterized by early-onset progressive ataxia with ocular motor apraxia (AOA1). APTX is foun...
Guardado en:
| Publicado en: | Sci Rep |
|---|---|
| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2015
|
| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4530458/ https://ncbi.nlm.nih.gov/pubmed/26256098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12876 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|