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Slow mitochondrial repair of 5′-AMP renders mtDNA susceptible to damage in APTX deficient cells
Aborted DNA ligation events in eukaryotic cells can generate 5′-adenylated (5′-AMP) DNA termini that can be removed from DNA by aprataxin (APTX). Mutations in APTX cause an inherited human disease syndrome characterized by early-onset progressive ataxia with ocular motor apraxia (AOA1). APTX is foun...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4530458/ https://ncbi.nlm.nih.gov/pubmed/26256098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12876 |
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