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beta-glucuronidase, a regulator of Lyme arthritis severity, modulates lysosomal trafficking and MMP-9 secretion in response to inflammatory stimuli

The lysosomal enzyme beta-glucuronidase (Gusb) is a key regulator of Lyme-associated and K/B×N-induced arthritis severity. The luminal enzymes present in lysosomes provide essential catabolic functions for the homeostatic degradation of a variety of macromolecules. In addition to this essential cata...

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Bibliografische gegevens
Gepubliceerd in:J Immunol
Hoofdauteurs: Bramwell, Kenneth K.C., Mock, Kelton, Ma, Ying, Weis, John H., Teuscher, Cory, Weis, Janis J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530054/
https://ncbi.nlm.nih.gov/pubmed/26170381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500212
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