Borrelia burgdorferi arthritis associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of Type I IFN production

Localized upregulation of Type I IFN was previously implicated in development of Borrelia burgdorferi induced arthritis in C3H mice, and was remarkable due to its absence in the mildly arthritic C57BL/6 (B6) mice. Independently, forward genetics analysis identified a quantitative trait locus (QTL) o...

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Veröffentlicht in:J Immunol
Hauptverfasser: Ma, Ying, Bramwell, Kenneth K.C., Lochhead, Robert B., Paquette, Jackie K., Zachary, James F., Weis, John H., Teuscher, Cory, Weis, Janis J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258437/
https://ncbi.nlm.nih.gov/pubmed/25378596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401746
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