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Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease.

The microtubule associated protein tau is incorporated into the pronase resistant core of the paired helical filament (PHF) in such a way that the repeat region is protected from proteases, but can be released as a major 12 kDa species from the PHF core by formic acid treatment and by boiling in SDS...

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Detalhes bibliográficos
Main Authors: Jakes, R, Novak, M, Davison, M, Wischik, C M
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC452980/
https://ncbi.nlm.nih.gov/pubmed/1915258
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